Standardized maximim D -optimal designs for enzyme kinetic inhibition models
نویسندگان
چکیده
منابع مشابه
Potential application of D-optimal designs in the efficient investigation of cytochrome P450 inhibition kinetic models.
Correctly chosen d-optimal designs provide efficient experimental schemes when the aim of the investigation is to obtain precise estimates of parameters. In the current work, estimates of parameters refer to the enzyme kinetic parameters V(max) and K(m), but they also refer to the inhibition constant K(i). In general, this experimental approach is performed on a grid of values of the design var...
متن کاملOptimum Designs for the Equality of Parameters in Enzyme Inhibition Kinetic Models
A general model for enzyme kinetics with inhibition, the “mixed” inhibition model, simplifies to the non-competitive inhibition model when two of the parameters are equal. We reparamaterise the model and provide designs for investigating the equality of parameters, which corresponds to a scalar parameter δ being zero. For linear models T-optimum designs for discriminating between models in whic...
متن کاملShort Communication Potential Application of D-Optimal Designs in the Efficient Investigation of Cytochrome P450 Inhibition Kinetic Models
Correctly chosen D-optimal designs provide efficient experimental schemes when the aim of the investigation is to obtain precise estimates of parameters. In the current work, estimates of parameters refer to the enzyme kinetic parameters Vmax and Km, but they also refer to the inhibition constant Ki. In general, this experimental approach is performed on a grid of values of the design variables...
متن کاملShort Communication Potential Application of D-Optimal Designs in the Efficient Investigation of Cytochrome P450 Inhibition Kinetic Models
Correctly chosen D-optimal designs provide efficient experimental schemes when the aim of the investigation is to obtain precise estimates of parameters. In the current work, estimates of parameters refer to the enzyme kinetic parameters Vmax and Km, but they also refer to the inhibition constant Ki. In general, this experimental approach is performed on a grid of values of the design variables...
متن کاملShort Communication Potential Application of D-Optimal Designs in the Efficient Investigation of Cytochrome P450 Inhibition Kinetic Models
Correctly chosen D-optimal designs provide efficient experimental schemes when the aim of the investigation is to obtain precise estimates of parameters. In the current work, estimates of parameters refer to the enzyme kinetic parameters Vmax and Km, but they also refer to the inhibition constant Ki. In general, this experimental approach is performed on a grid of values of the design variables...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemometrics and Intelligent Laboratory Systems
سال: 2017
ISSN: 0169-7439
DOI: 10.1016/j.chemolab.2017.08.009